Research & Biophotonics Laser Solutions for Scientists & Labs:
User-Friendly, High-Performance Laser Solutions That Speed Discovery and Ensure Your Work Gets Published
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Exact wavelength, pulse width, and jitter your protocol demands – standard or custom-tuned pulsed, CW, and diode lasers to fit your exact needs
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We’ll match the right laser to your experiment, so you get the data you need – collaborating with you and our engineers to provide you full support
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Thousands of units powering core facilities and Principal Investigators – from imaging & microscopy to spectroscopy, DNA sequencing & beyond
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Streamlined lab integration with turn-key plug-and-play options – User-friendly GUIs, remote diagnostics, air-cooling & much more
30 Years Enabling Quality Data Collection to Power Your Next Breakthrough
Show me Research & Biophotonics Laser Sources!
Tackle your toughest research challenges with RPMC’s expertise & lab-ready lasers:
Scope realigned daily because the beam wanders overnight? RPMC can help:
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- Budget Crunch
Every dollar counts – finding high-performance lasers that fit the line-item is brutal - Not Sure What You Need
Hundreds of specs, dozens of vendors – picking the wrong one kills the experiment - Spec Sheet Shock
The datasheet looks perfect – until you discover it needs 3 kV and liquid nitrogen… - Trigger-Timing Shortfalls
Your TCSPC card wants 200 fs jitter from the fs laser; every vendor quotes 2 ps - Mode-Hopping Mad
Lacking stability, the laser temperature drifts and your STED resolution disappears
We get your pain – RPMC provides expert technical guidance from first contact through installation and beyond, modular solutions to fit your budget, remote diagnostics to get you up and running faster, and much more! Tell us about YOUR challenges:
Explore real-world lab Success Stories: RPMC’s solutions drive successful projects
RPMC empowers researchers, from PIs to post-docs and core-facility directors with user-friendly, high-performance laser solutions tailored to your most ambitious experiments. Our 30 years of lab-floor expertise ensure seamless collaboration, from matching the perfect wavelength to custom-tuning pulse width, jitter, or trigger for your protocol. We prioritize publication speed, grant leverage, and zero-hassle integration, delivering lab-proven laser sources that keep your data flowing. With thousands of units powering confocal, STED, optogenetics, and Raman setups worldwide, our end-to-end support, personalized technical guidance, and rapid response times help turn proposals into DOIs.
Our laser solutions power real breakthroughs for research labs like yours:
Research & Biophotonics Success Stories

RPMC supported cell biologists conducting multi-color fluorescence experiments who were frustrated by the need to constantly swap filter sets or endure slow monochromator scans, which disrupted workflows, bleached sensitive samples, and prevented true simultaneous imaging of multiple cellular structures. RPMC delivered a versatile broadband illumination system paired with a rapid wavelength selector, allowing instant excitation tuning across the spectrum while maintaining high intensity and stability – eliminating mechanical delays and enabling clean, real-time capture of co-localized fluorophores in fixed and live specimens.
Laser Solution: Fiber-delivered broadband light source with flexible wavelength selector, tunable from UV to near-IR, used for multi-color fluorescence imaging.
Outcome: Simplified setups and boosted signal reliability, enabling faster, gentler imaging of live cells and tissues.

RPMC and our partners collaborated with combustion researchers who were grappling with the inability of conventional sensors to deliver reliable, real-time data in the extreme heat, pressure, and chemical chaos of flame environments – a classic pain point where interference overwhelms signal and response lags hinder dynamic control. By supplying a robust quantum cascade laser platform tailored for harsh conditions, RPMC enabled the team to push beyond these barriers without compromising sensitivity or stability.
Laser Solution: Fiber-coupled mid-IR quantum cascade laser, tunable with narrow linewidth, used for sensitive absorption spectroscopy.
Outcome: Ensured stable, real-time radical monitoring under harsh conditions, driving progress toward more efficient and lower-emission combustion systems.

A team of bio researchers was pursuing label-free lipid imaging in living organisms and tissue sections, but single-wavelength systems failed to target specific vibrational bonds while synchronization drifts degraded coherent signal strength. Utilizing a synchronized dual-output femtosecond laser with fixed and tunable arms optimized for the CH-stretch region, complete with built-in delay compensation for plug-and-play CARS contrast in open-table microscopes.
Laser Solution: Free-space dual-wavelength femtosecond laser, one fixed and one tunable in the near-IR with temporal overlap, used for coherent anti-Stokes Raman scattering (CARS).
Outcome: Facilitated high-specificity, non-invasive visualization of lipids and molecular distributions, advancing metabolic and neurological studies in model organisms and human samples.

A group of neuroscientists were imaging awake animals and large cleared organs, where conventional confocal systems suffered from shallow penetration, high photodamage, and inability to capture label-free structural signals in thick samples. The team integrated a turnkey femtosecond source enabling multimodal nonlinear excitation—including two-photon fluorescence, SHG, and THG—paired with tissue-clearing compatibility and wide working distance objectives for macro-to-micro versatility.
Laser Solution: Free-space femtosecond laser, tunable in the near-IR with ultrashort pulses, used for multiphoton and harmonic generation microscopy.
Outcome: Unlocked deep, non-destructive 3D/4D imaging with reduced phototoxicity, revealing functional and structural biomarkers across scales in live and fixed specimens.

RPMC partnered with materials scientists performing laser-induced breakdown spectroscopy (LIBS) on challenging alloys, where insufficient pulse energy produced weak plasma emission and inconsistent elemental signatures under ambient conditions. RPMC delivered an air-cooled, high-peak-power DPSS laser with innovative end-pumping and optional harmonics, ensuring stable, high-quality beams without water chilling or frequent diode replacements even during prolonged field campaigns.
Laser Solution: Free-space diode-pumped solid-state laser, sub-nanosecond to nanosecond pulses from UV to near-IR with high energy per pulse, used for plasma generation in LIBS and ablation.
Outcome: Enabled robust, low-maintenance spectral analysis in remote or harsh settings, supporting reliable material identification and process monitoring.

RPMC assisted environmental researchers deploying standoff detection systems who needed wavelength scanning across broad mid-IR gaps but were limited by sluggish manual tuning and pump laser incompatibilities in portable setups. RPMC supplied a fully automated, high-repetition-rate OPO with microprocessor-controlled alignment and bypass access to the pump line, allowing hands-free operation from any web interface while fitting into compact, air-cooled enclosures.
Laser Solution: Free-space optical parametric oscillator (OPO), broadly tunable in the near-IR with high repetition rate, used for vibrational spectroscopy and remote sensing.
Outcome: Provided seamless, remote-managed spectral agility in field-deployable systems, improving real-time pollutant tracking and standoff analysis efficiency.

RPMC worked alongside neuroscientists pursuing minimally invasive optical control of brain circuits, but conventional pulse durations either overheated tissue or failed to generate sufficient acoustic waves—leaving a narrow window for safe, effective stimulation (photoacoustic vs photothermal stimulation) that most off-the-shelf lasers couldn’t hit. RPMC provided a precisely engineered DPSS source that balanced peak power and thermal confinement, giving the lab confidence to scale from in vitro to in vivo models without protocol rework.
Laser Solution: Free-space near-IR nanosecond laser with high peak power and ultrashort pulses, used for photoacoustic neural activation.
Outcome: Provided precise, low-heat stimulation with excellent targeting, enhancing safety and repeatability in neural circuit mapping.

A team of energy researchers developing hydrogen and ammonia combustion systems faced major hurdles in detecting trace emission species at ultra-low concentrations within turbulent, high-pressure gas flows—creating a critical roadblock to validating carbon-free fuel performance under real engine conditions. By deploying mid-infrared quantum cascade lasers with high-speed pulsing and robust environmental packaging, the group achieved stable, real-time absorption measurements even at extreme temperatures, eliminating interference and enabling precise kinetic modeling without invasive sampling.
Laser Solution: Fiber-coupled tunable quantum cascade laser in the mid-IR, narrow linewidth with high-speed pulsing, used for real-time emission and composition analysis.
Outcome: Delivered reliable sub-part-per-million sensitivity in dynamic environments, supporting optimized fuel blending and reduced carbon impact.

RPMC assisted a hyperspectral imaging team bogged down by broadband lamps that delivered uneven intensity and required constant recalibration, turning what should have been routine chemical mapping into hours of troubleshooting and compromised datasets. RPMC introduced a turnkey tunable platform that locked in wavelength accuracy and power stability, transforming slow, noisy scans into fast, publication-ready spectral imaging results across diverse samples from semiconductors to biological tissues.
Laser Solution: Free-space tunable laser system with narrow linewidth across visible to near-IR, used for high-resolution hyperspectral imaging.
Outcome: Enabled fast, clear chemical mapping with minimal noise, improving efficiency in microscopy and material analysis workflows.

RPMC partnered with a multidisciplinary research group frustrated by bulky, inflexible laser systems that forced lengthy setup changes and introduced variability during wavelength-critical nonlinear experiments—issues that routinely delayed data collection and eroded confidence in spectral fidelity. RPMC delivered a compact, user-friendly picosecond pulsed DPSS solution that integrated seamlessly into existing optical benches, restoring momentum to time-sensitive studies in vibrational imaging and molecular dynamics.
Laser Solution: Free-space femtosecond laser, broadly tunable in the near-IR with ultrashort pulses and high repetition rate, used for label-free vibrational spectroscopy.
Outcome: Streamlined rapid spectral scanning with consistent performance, accelerating breakthroughs in biomolecular and materials research.
RPMC has provided laser sources for many successful Research & Biophotonics applications:
RPMC’s success is driven by our dedicated team & the invaluable support of our skilled & innovative manufacturers.
Explore our wide range of laser technology, powering those Research Success Stories
RPMC’s hand-picked portfolio of precision lasers fuels your next breakthrough—from single-molecule imaging to high-speed spectroscopy—delivering clean, repeatable data with minimal bench-time tweaks.
Our lab-ready lineup spans low-noise CW diodes to femtosecond fiber systems, seed modules, tunable OPOs, and compact amplifiers, all built for drop-in use with your existing microscope, flow cytometer, or custom breadboard.
Dive into the research laser groups below, each tied to core biophotonics techniques, with on-the-fly adjustments for linewidth, rep-rate, trigger jitter, and beam profile—dialed in to match your grant proposal line-for-line.
| Application Group | Application | Supporting Laser Categories |
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| Imaging & Analysis |
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| Spectroscopy & Analysis |
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| Measurement & Analysis |
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| Molecular Manipulation & Analysis |
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Custom Research & Biophotonics Laser Solutions:
Wafers to Components, Breadboard, and Turn-Key Rack-Mount Systems
Despite providing > 10,000 standard SKUs, your next DOI often demands a one-off. Our world-class partners will collaborate with you to define specifications and help you get the exact right solution, tailored to the unique needs of your specific application.
Tailored Laser Solutions for:
• Confocal & STED Super-Resolution • FLIM & FCS Lifetime Mapping • Optogenetics & FRAP • Raman & CARS Spectroscopy • LIBS & MALDI-TOF • PIV & LDV Flow Imaging • Optical Tweezers & DNA Origami • Fiber-Seeded OPA/OPG Chains •
Learn More About RPMC’s Customization Capabilities
See why PIs trust RPMC for their next publication
RPMC at a Glance:
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30 years in labs 
10,000+ standard lasers 
1000s of units in core facilities 
Industry-leading laser sources 
Endless customization options 
Personalized support 
Flexible & agile – no red tape 
US-Made options 
Buffer stock for grant rushes 
Just-in-time deliveries “RPMC provided the critical light source we needed to get our research published!”
~YOUR Name Here (IF you Contact Us!)
Small Enough to Care, Big Enough to Deliver
For 30 years, RPMC has powered confocal fluorescence microscopy to Raman spectroscopy in universities and national labs across the US. Our lab-experienced team, supported by leading engineering partners, helps you move from initial wavelength selection to final trigger integration, with modular laser solutions that fit your existing breadboard or core-facility setup.
We address common research hurdles, providing lab-proven configurable lasers to fit your budget, tailored with the right specifications that support reliable data collection, no matter what application you’re working with.
As a responsive, agile small business, we deliver expert-level guidance, grant-ready quotes, and direct access to manufacturer expertise for streamlined integration support to keep your experiments running smoothly and your publications on track.
RPMC is your lab’s trusted laser partner for advancing scientific discovery.
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